Enantioselective construction of highly substituted pyrrolidines by palladium-catalyzed asymmetric [3+2] cycloaddition of trimethylenemethane with ketimines.

Abstract

The transition-metal catalyzed trimethylenemethane [3+2] cycloaddition provides a direct route to functionalized heterocycles. Herein, we describe a protocol for the reaction between 1-cyano-2-((trimethylsilyl)methyl)allyl acetate and a series of ketimines to generate highly substituted pyrrolidines. This methodology showcases a catalytic, asymmetric… (More)
DOI: 10.1021/ja102102d

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