Enantioselective Synthesis of Functionalized 4-Aryl Hydrocoumarins and 4-Aryl Hydroquinolin-2-ones via Intramolecular Vinylogous Rauhut-Currier Reaction of para-Quinone Methides.

@article{Zhang2017EnantioselectiveSO,
  title={Enantioselective Synthesis of Functionalized 4-Aryl Hydrocoumarins and 4-Aryl Hydroquinolin-2-ones via Intramolecular Vinylogous Rauhut-Currier Reaction of para-Quinone Methides.},
  author={Xiang‐Zhi Zhang and Kang-Ji Gan and Xiao-Xue Liu and Yuhua Deng and Fang-Xin Wang and Ke‐Yin Yu and Jing Zhang and Chun‐An Fan},
  journal={Organic letters},
  year={2017},
  volume={19 12},
  pages={
          3207-3210
        }
}
A novel strategy for the asymmetric construction of functionalized 4-aryl-3,4-dihydrocoumarins and 4-aryl-3,4-dihydroquinolin-2-ones via an intramolecular vinylogous Rauhut-Currier reaction of para-quinone methides (p-QMs) under the bifunctional catalysis of chiral amine-phosphine is described. This intramolecular mode for the catalytic enantioselective 1,6-conjugate addition of p-QMs has been explored for the first time, delivering two types of synthetically important heterocycles in high… 
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76 Citations

76 Citations

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