Enantioselective Organocatalytic Transfer Hydrogenation of 1,2-Dihydroquinoline through Formation of Aza-o-xylylene.

Abstract

A new way of forming the aza-o-xylylene with easily accessible 1,2-dihydroquinolines as precursor has been developed. The presence of an electron-donating group at the proper position of 1,2-dihydroquinoline was crucial for protonation of the alkene through dearomatization with a simple Brønsted acid. The in situ forming reactive intermediate was trapped… (More)
DOI: 10.1021/acs.orglett.5b02025

Topics

Cite this paper

@article{Li2015EnantioselectiveOT, title={Enantioselective Organocatalytic Transfer Hydrogenation of 1,2-Dihydroquinoline through Formation of Aza-o-xylylene.}, author={Guangxun Li and Hongxin Liu and Gang Lv and Yingwei Wang and Qingquan Fu and Zhuo Tang}, journal={Organic letters}, year={2015}, volume={17 17}, pages={4125-7} }