Enantioselective Kinetics of Verapamil and Norverapamil in Isolated Perfused Rat Livers


The kinetics of the individual enantiomers of verapamil (VER) and its metabolite, norverapamil (NOR), were studied in isolated perfused rat livers (IPRLs) after administration of racemic drug or the preformed metabolite. After constant infusion of 20 µg/min of racemic VER to single-pass IPRLs, the hepatic availabilities (F) of the enantiomers were low (S… (More)
DOI: 10.1023/A:1018935921473