Enantioselective Effects of Hydroxy Metabolites of Bupropion on Behavior and on Function of Monoamine Transporters and Nicotinic Receptors

  title={Enantioselective Effects of Hydroxy Metabolites of Bupropion on Behavior and on Function of Monoamine Transporters and Nicotinic Receptors},
  author={M. I. Damaj and F. Carroll and J. Eaton and H. Navarro and B. Blough and Sadiq Mirza and R. Lukas and B. Martin},
  journal={Molecular Pharmacology},
  pages={675 - 682}
  • M. I. Damaj, F. Carroll, +5 authors B. Martin
  • Published 2004
  • Chemistry, Medicine
  • Molecular Pharmacology
  • Bupropion is an atypical antidepressant that also has usefulness as a smoking-cessation aid. Because hydroxybupropion, a major metabolite of bupropion, is believed to contribute to its antidepressant activity, this metabolite may also contribute to the smoking-cessation properties of bupropion. This study investigated the effects of hydrobupropion enantiomers on monoamine transporters and nicotinic acetylcholine receptor (nAChR) subtypes. Racemic bupropion and hydroxybupropion inhibit [3H… CONTINUE READING
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