Enantioresolution of five β-blockers by reversed-phase high-performance liquid chromatography using fifteen chiral derivatizing reagents having amino acids or their amides as chiral auxiliaries on a cyanuric chloride platform.

@article{Bhushan2012EnantioresolutionOF,
  title={Enantioresolution of five β-blockers by reversed-phase high-performance liquid chromatography using fifteen chiral derivatizing reagents having amino acids or their amides as chiral auxiliaries on a cyanuric chloride platform.},
  author={R. Bhushan and Shuchi Dixit},
  journal={Biomedical chromatography : BMC},
  year={2012},
  volume={26 2},
  pages={
          239-46
        }
}
  • R. Bhushan, Shuchi Dixit
  • Published 2012
  • Chemistry, Medicine
  • Biomedical chromatography : BMC
  • Enantioseparation of five β-blockers, namely, (R,S)-atenolol, (R,S)-propranolol, (R,S)-bisoprolol, (R,S)-metoprolol and (R,S)-carvedilol, was achieved as their diastereomers prepared with chiral derivatizing reagents (CDRs) synthesized on a cyanuric chloride platform. Fifteen CDRs were synthesized by nucleophilic substitution of the Cl atom in cyanuric chloride or its 6-methoxy derivative with amino acids (namely, L-Leu, L-Val, D-Phg, L-Met and L-Ala) or their amides as chiral auxiliaries. The… CONTINUE READING
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