Enantiomerically enriched allylic alcohols and allylic amines via C-C bond-forming hydrogenation: asymmetric carbonyl and imine vinylation.

@article{Skucas2007EnantiomericallyEA,
  title={Enantiomerically enriched allylic alcohols and allylic amines via C-C bond-forming hydrogenation: asymmetric carbonyl and imine vinylation.},
  author={Eduardas Skucas and Ming-Yu Ngai and Venukrishnan Komanduri and Michael J Krische},
  journal={Accounts of chemical research},
  year={2007},
  volume={40 12},
  pages={
          1394-401
        }
}
  • Eduardas Skucas, Ming-Yu Ngai, +1 author Michael J Krische
  • Published in Accounts of chemical research 2007
  • Chemistry, Medicine
  • Hydrogenation of alkynes in the presence of carbonyl compounds and imines using cationic rhodium(I) and iridium(I) precatalysts enables the formation of allylic alcohols and allylic amines, respectively. Through the use of hydrogenation catalysts modified by chiral ligands, allylic alcohols and allylic amines may be generated in highly optically enriched forms. Hydrogenative fragment couplings of this type circumvent the use of preformed organometallic reagents and avoid the generation of… CONTINUE READING

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