Enantiomeric separation using an l-RNA aptamer as chiral additive in partial-filling capillary electrophoresis.

@article{Ruta2006EnantiomericSU,
  title={Enantiomeric separation using an l-RNA aptamer as chiral additive in partial-filling capillary electrophoresis.},
  author={Jos{\'e}phine Ruta and Corinne Ravelet and Catherine Grosset and Jennifer Fize and Anne Ravel and Annick Villet and Eric Peyrin},
  journal={Analytical chemistry},
  year={2006},
  volume={78 9},
  pages={3032-9}
}
In this paper, we report the chiral resolution of arginine using an anti-arginine l-RNA aptamer chiral selector in partial-filling CE. The effects of the capillary temperature, sample load, and aptamer plug length on the enantiomeric separation were assessed. Very high chiral resolving capability was observed at low or moderate capillary temperatures (the target peak being not detected in the separation window), whereas the practical chiral resolution was achieved only at high enough… CONTINUE READING