Enantiomeric separation of drugs and herbicides on a beta-cyclodextrin-bonded stationary phase.

  title={Enantiomeric separation of drugs and herbicides on a beta-cyclodextrin-bonded stationary phase.},
  author={Fairouz Tazerouti and Ahmed Yacine Badjah-Hadj-Ahmed and Brahim Youcef Meklati and Pilar Franco and Cristina Minguillón},
  volume={14 1},
A chemically bonded beta-cyclodextrin chiral stationary phase for HPLC was prepared in a "one pot" process by the reaction of a phenylated beta-cyclodextrin with silica gel. Various racemic analytes such as drugs (aminoalcohol adrenergic beta-blockers, benzodiazepine anxiolytics, arylpropionic acid antiinflammatory agents) and herbicides (aryloxypropionic acids and esters) were separated on the prepared material. The column showed good chiral recognition ability for most of the solutes tested… 
Application of Native and Hydroxypropyl-Substituted β-Cyclodextrin Bonded Silica Gel as Stationary Phases for High Performance Liquid Chromatography
Two chiral stationary phases for high-performance liquid chromatography (HPLC) have been synthesized by grafting native and 2-hydroxypropyl-β-cyclodextrin onto silica gel by a previously described
HPLC Separation and Determination of Enantiomeric Purity of Novel Nucleoside Analogs, on Cyclodextrin Chiral Stationary Phases, Using Reversed and Polar Organic Modes
Abstract This work reports a method for the determination of the purity of some potential antiviral agents by analytical HPLC. Such agents are nucleoside analogs, which possess one chiral center and
Preparation and enantioseparation characteristics of three chiral stationary phases based on modified β-cyclodextrin for liquid chromatography
Three mixed 10-undecenoate/phenylcarbamate derivatives of β-cyclodextrin have been prepared and linked to allylsilica gel by means of a radical reaction, and the chiral recognition ability of the resulting materials was evaluated.
Preparation and chromatographic properties of a multimodal chiral stationary phase based on phenyl-carbamate-propyl-beta-CD for HPLC.
A phenylcarbamate derivative of 2-hydroxypropyl-beta-CD bonded stationary phase was prepared and seems to have an excellent enantioselectivity for a variety of racemic analytes in the three modes, hence it can be considered a highly effective multimodal column.
Analysis of the Mechanism of Retention on a Modified β‐Cyclodextrin/Silica Chiral Stationary Phase using a Computational Chemical Method
Abstract Quantitative analysis of the retention of various optically active solutes on a modified β‐cyclodextrin/silica chiral stationary phase was achieved using a molecular mechanics calculation of
Chiral Recognition Mechanisms of four β-Blockers by HPLC with Amylose Chiral Stationary Phase
The high performance liquid chromatography (HPLC) enantioseparation of four β-blocking agents metoprolol, bisoprolol, propranolol and atenolol was performed on amylose
Enantiomeric separation of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs and β-blockers by RP-HPLC using an amylose chiral stationary phase for the enantioselective skin permeation study
The enantioselectivities of eight 2-arylpropionic acid nonsteroidal anti-inflammatory drugs (2-APA NSAIDs) and two β-blockers on an amylose-tris(3,5-dimethylphenylcarbamate)-based Chiralpak AD-RH
Chromatographic behavior of ion pair enantiomers of dansyl leucine cyclohexylammonium salt on a beta-cyclodextrin stationary phase and the effect of a competitive-binding mobile phase additive.
1-adamantanecarboxylic acid is investigated as a solute-competitive mobile phase additive to intentionally block the hydrophobic cyclodextrin cavities on the stationary phase to provide thermodynamic insight into the major enantioselective driving forces of separation.


Chromatographic properties in normal-mode HPLC of chiral stationary phases based on substituted β-cyclodextrins
SummarySubstituted β-cyclodextrin chiral stationary phases having different types of phenyl carbamate substituents have been prepared and evaluated (retention, selectivity, resolution) for the liquid
Derivatized cyclodextrins for normal-phase liquid chromatographic separation of enantiomers
Several different derivatized {beta}-cyclodextrins were synthesized and used as chiral stationary phases in normal-phase liquid chromatography. The multiply substituted derivatives were made with
Synthesis and chromatographic properties of HPLC chiral stationary phases based upon β-cyclodextrins
Summaryβ-cyclodextrin chiral stationary phases (CD-CSP) having different spacer lengths have been prepared and evaluated (retention, selectivity, resolution) for the liquid chromatographic separation
Retention behavior and chiral recognition mechanism of several cyclodextrin-bonded stationary phases for dansyl amino acids
Five types of natural and chemically modified β-or γ-cyclodextrin-bonded stationary phases have been prepared and their ability to separate enantiomers of 12 dansyl amino acids was investigated by
Retention and enantioselectivity properties of β-cyclodextrin polymers and derivatives on porous silica for reverse-phase liquid chromatographic separation of enantiomers
SummaryChiral stationary phases (CSP) based on porous silica coated with β-cyclodextrin polymer and methylated or acetylated derivatives have been prepared. Their enantiomer separation capability was
Optical Resolution of Some Mandelic Derivatives on a Chemically Bonded Cyclodextrin Stationary Phase
Preparation and use of a new type of cyclodextrin-bonded stationary phase are described. Resolution of racemic mandelates and their analogues has been achieved by using this phase. The chiral
Direct enantiomeric separations by high performance liquid chromatography using cyclodextrins.
  • S. Han
  • Chemistry
    Biomedical chromatography : BMC
  • 1997
The historical development of derivatized and underivatized cyclodextrins in HPLC and their various applications are described.
HPLC of Structural Isomers Using Cyclodextrin-Poly(vinylamine)-Coated Silica Columns, Part II: Retention Behavior and Separation
The liquid chromatographic retention behavior and separation by isocratic elution of aromatic compounds by using several β-cyclodextrin bonded stationary phases is investigated. The highperformance