Enantiomeric resolution of a novel chiral cannabinoid receptor ligand.


The enantiomeric resolution of a racemic novel cannabinoid receptor ligand conformationally restricted at the southern aliphatic chain was accomplished using a ChiralPak AD column. Both enantiomers were tested for their competitive binding to the rat brain CB1, mouse spleen CB2 and human CB2 receptors. The levorotatory isomer showed exceptionally high affinity for the CB1 receptor with a seven-fold selectivity over CB2.

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@article{Thakur2002EnantiomericRO, title={Enantiomeric resolution of a novel chiral cannabinoid receptor ligand.}, author={Ganesh A Thakur and Sonya L Palmer and Paul E Harrington and Ioanna A Stergiades and Marcus A Tius and Alexandros Makriyannis}, journal={Journal of biochemical and biophysical methods}, year={2002}, volume={54 1-3}, pages={415-22} }