Enantiomeric recognition of racemic 4-aryl-1,4-dihydropyridine derivatives via chiralpak AD-H stationary phases.

@article{Dai2012EnantiomericRO,
  title={Enantiomeric recognition of racemic 4-aryl-1,4-dihydropyridine derivatives via chiralpak AD-H stationary phases.},
  author={Zhi Dai and C. U. Pittman and Tingyu Li},
  journal={Chirality},
  year={2012},
  volume={24 10},
  pages={854-9}
}
The chromatographic chiral resolution of two new series of racemic 4-substituted-1,4-dihydropyridine derivatives was studied on a commercial Chiralpak AD-H column. Analytes without 5,5-dimethyl substituents (1-15) are more efficiently resolved than analytes with 5,5-dimethyl groups (16-30). The AD-H column discriminated between enantiomers through both hydrogen bonding attractions and π-π interactions. This interpretation is in accord with plots of the logarithm of separation factors, log… CONTINUE READING