Enantiomeric determination of amlodipine in human plasma by liquid chromatography coupled to tandem mass spectrometry.

@article{Streel2002EnantiomericDO,
  title={Enantiomeric determination of amlodipine in human plasma by liquid chromatography coupled to tandem mass spectrometry.},
  author={Bruno Streel and Christiane Laine and Carl Zimmer and R Sibenaler and Attilio Ceccato},
  journal={Journal of biochemical and biophysical methods},
  year={2002},
  volume={54 1-3},
  pages={357-68}
}
A sensitive method for the separation and determination of amlodipine enantiomers in plasma has been developed based on solid-phase extraction (SPE) with disposable extraction cartridges (DECs) in combination with chiral liquid chromatography (LC). The SPE technique is used to isolate the drug from the biological matrix and to prepare a cleaner sample before injection and analysis by HPLC coupled to mass spectrometry. The DEC is filled with ethyl silica (50 mg) and is first conditioned with a 2… CONTINUE READING