Enantiomeric cross-inhibition in the synthesis of oligonucleotides on a nonchiral template.

Abstract

Peptide nucleic acids (PNA) are used as a model for a precursor of RNA in experiments that examine enantiomeric cross-inhibition. Experiments were conducted to facilitate comparison with prior research. Results indicate that enantiomeric cross-inhibition is as problematic in the polymerization of nucleotides on PNA as in RNA and DNA templates.

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@article{Schmidt1997EnantiomericCI, title={Enantiomeric cross-inhibition in the synthesis of oligonucleotides on a nonchiral template.}, author={J. G. Schmidt and Peter E. Nielsen and Leslie E . Orgel}, journal={Journal of the American Chemical Society}, year={1997}, volume={119 6}, pages={1494-5} }