Enantiomer ratio of MK-0767 in humans and nonclinical species.


MK-0767, (+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)phenyl]methyl]benzamide, is a thiazolidinedione-containing dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that has been studied as a potential treatment for patients with type 2 diabetes. MK-0767 contains a chiral center at the C-5 position of… (More)


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@article{Shen2005EnantiomerRO, title={Enantiomer ratio of MK-0767 in humans and nonclinical species.}, author={Zhongzhou Shen and Ray Bakhtiar and Masakatsu Komuro and Katsuya Awano and Fukutaro Taga and Adria E Colletti and Don Hora and William P Feeney and Susan A. Iliff and Ronald B. Franklin and Stella E Vincent}, journal={Rapid communications in mass spectrometry : RCM}, year={2005}, volume={19 9}, pages={1125-9} }