Enantioenriched β-lactone and aldol-type products from regiodivergent carbonylation of racemic cis-epoxides

  title={Enantioenriched $\beta$-lactone and aldol-type products from regiodivergent carbonylation of racemic cis-epoxides},
  author={Michael Mulzer and W. Chadwick Ellis and Emil B. Lobkovsky and Geoffrey W. Coates},
  journal={Chemical Science},
A new carbonylation catalyst is reported that provides enantioenriched β-lactones and aldol-type products from the carbonylative ring-expansion of racemic cis-epoxides. Detailed analysis of the reaction demonstrates that the epoxide substrates undergo regiodivergent carbonylation reactions instead of traditional kinetic resolutions. This new catalytic system was applied to the synthesis of a key fragment of the antibiotic Globomycin. 
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