Enantio- and regioselective iridium-catalyzed allylic hydroxylation.


The first enantioselective allylic hydroxylation to prepare branched allylic alcohols directly is described. Bicarbonate was used as nucleophile in conjunction with new single component Ir-catalysts, which are stable to air and water. Excellent regio- and enantioselectivities have been achieved with a representative set of substrates. 
DOI: 10.1021/ja109953v

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