Enantio- and Diastereoswitchable C-H Arylation of Methylene Groups in Cycloalkanes.

@article{Andr2019EnantioAD,
  title={Enantio- and Diastereoswitchable C-H Arylation of Methylene Groups in Cycloalkanes.},
  author={Michal Sascha Andr{\"a} and Lukas Schifferer and Corina H. Pollok and Christian Merten and Lukas J. Goossen and Jin-Quan Yu},
  journal={Chemistry},
  year={2019}
}
A complementary set of chiral N,N-ligands enables the Pd-catalyzed β-C-H arylation of unbiased internal methylene groups in good yield and with high levels of enantio- and diastereoinduction. Both the dia- and enantioselectivity can be reversed, thus allowing the selective arylation of any of the four β-C-H bonds in cycloalkanecarboxamides of various ring sizes. The method is applicable to a broad range of aryl iodides with electron-withdrawing and -donating substituents in the o-, m-, or p… CONTINUE READING

Topics from this paper.