Enaminonitriles in heterocyclic synthesis: a route to 1,3-diaryl-4-aminopyrazole derivatives.

Abstract

Benzylcyanide and 4-nitrobenzylcyanide condensed with triethyl orthoformate and piperidine or morpholine to yield 2-aryl-2-piperidinyl or 2-morpholinylacrylonitriles. These coupled with aromatic diazonium salts to yield the 2-arylhydrazno-2-arylethane nitriles in good yields. The latter were converted into 4-aminopyrazoles in good yields using the Thorpe-Ziegler cyclization.

DOI: 10.3390/molecules18010535

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Cite this paper

@article{Medrasi2013EnaminonitrilesIH, title={Enaminonitriles in heterocyclic synthesis: a route to 1,3-diaryl-4-aminopyrazole derivatives.}, author={Hanadi Y. Medrasi and Mariam Abdullah Al-Sheikh and Abdellatif Mohamed Salaheldin}, journal={Molecules}, year={2013}, volume={18 1}, pages={535-44} }