Enamel matrix derivative stimulates core binding factor alpha1/Runt-related transcription factor-2 expression via activation of Smad1 in C2C12 cells.

@article{Takayama2005EnamelMD,
  title={Enamel matrix derivative stimulates core binding factor alpha1/Runt-related transcription factor-2 expression via activation of Smad1 in C2C12 cells.},
  author={Tadahiro Takayama and Naoto Suzuki and Masataka Narukawa and Tsuyoshi Tokunaga and Kichibee Otsuka and Koichi Ito},
  journal={Journal of periodontology},
  year={2005},
  volume={76 2},
  pages={244-9}
}
BACKGROUND Although enamel matrix derivative (EMD) can promote osteogenic differentiation of the pluripotent mesenchymal precursor cell line, C2C12, the molecular mechanism that underlies this phenomenon is unclear. The purpose of this study was to determine which molecules in EMD stimulate osteogenic differentiation. METHODS C2C12 cells were cultured in 5% serum-containing medium to induce differentiation, either with or without the addition of EMD. The expression of core binding factor… CONTINUE READING

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