Enalaprilat improves systemic and mesenteric blood flow during resuscitation from hemorrhagic shock in dogs.

@article{Wall2003EnalaprilatIS,
  title={Enalaprilat improves systemic and mesenteric blood flow during resuscitation from hemorrhagic shock in dogs.},
  author={Piper L. Wall and Charisse M. Buising and L K Henderson and Brian Freeman and R{\'e}quillart Vincent and Jeffrey B Albright and Norman F. Paradise},
  journal={Shock},
  year={2003},
  volume={19 3},
  pages={
          289-96
        }
}
We investigated the systemic and mesenteric cardiovascular effects of administering enalaprilat during resuscitation from hemorrhage. Dogs were hemorrhaged (mean arterial pressure [MAP] 40-45 mmHg for 30 min, then 30-35 mmHg for 30 min) and were then resuscitated with intermittent lactated Ringer's solution (200 mL/kg/h during first 40 min, and 60 mL/kg/h during the following 130 min, MAP 75-80 mmHg). A constant-rate infusion of saline with or without enalaprilat (0.02 mg/kg/h) was initiated… CONTINUE READING