Enalapril treatment increases T cell number and promotes polarization towards M1-like macrophages locally in diabetic nephropathy.

@article{Cucak2015EnalaprilTI,
  title={Enalapril treatment increases T cell number and promotes polarization towards M1-like macrophages locally in diabetic nephropathy.},
  author={Helena Cucak and Lisbeth Nielsen Fink and Maiken H\ojgaard Pedersen and Alexander Rosendahl},
  journal={International immunopharmacology},
  year={2015},
  volume={25 1},
  pages={30-42}
}
Diabetic nephropathy (DN) is a serious complication of longstanding diabetes affecting up to 30% of all diabetes patients and is the main cause of end-stage kidney disease globally. Current standard treatment e.g. ACE-inhibitors like enalapril merely offers a delay in the progression leading to DN. Herein, we describe in two preclinical models evidence to local effects on the inflammatory signatures after intervention treatment with enalapril which provides enhanced understanding of the… CONTINUE READING
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