Enalapril and captopril enhance glutathione-dependent antioxidant defenses in mouse tissues.

  title={Enalapril and captopril enhance glutathione-dependent antioxidant defenses in mouse tissues.},
  author={Elena M V de Cavanagh and Felipe Inserra and Le{\'o}n F. Ferder and Cesar G Fraga},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={278 3},
The effect of enalapril and captopril on total glutathione content (GSSG + GSH) and selenium-dependent glutathione peroxidase (Se-GPx) and glutathione reductase (GSSG-Rd) activities was investigated in mouse tissues. CF-1 mice (4-mo-old females) received water containing enalapril (20 mg/l) or captopril (50 mg/l) for 11 wk. Enalapril increased GSSG + GSH content (P < 0.05) in erythrocytes (147%), brain (112%), and lung (67%), and captopril increased GSSG + GSH content in erythrocytes (190%) and… CONTINUE READING


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