Emx2 patterns the neocortex by regulating FGF positional signaling

  title={Emx2 patterns the neocortex by regulating FGF positional signaling},
  author={Tomomi Fukuchi-Shimogori and Elizabeth Ann Grove},
  journal={Nature Neuroscience},
Molecular genetic studies implicate fibroblast growth factor 8 (FGF8), and the transcription factor Emx2, in development of the neocortical area map. Both are proposed to specify area position along the anterior-to-posterior axis of the cortical primordium. Whether FGF8 and Emx2 act independently or coordinately, or whether one controls the other, has not been determined. Here we report that Emx2, by regulating FGF8, has an indirect but vital role in area-map development. Using electroporation… CONTINUE READING
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