Emu oil(s): A source of non-toxic transdermal anti-inflammatory agents in aboriginal medicine

  title={Emu oil(s): A source of non-toxic transdermal anti-inflammatory agents in aboriginal medicine},
  author={Michael Whitehouse and A G Turner and C K Davis and Michael S. Roberts},
AbstractThe ‘oil’ obtained from emu fat can be a very effective inhibitor of chronic inflammation in rats when applied dermally (with a skin penetration enhancer). Assays for this activity using the adjuvant-induced arthritis model have shown:i.Considerable variability in potency of some commercial oil samples;ii.Little or no correlation of activity with colour or linolenic acid (18:3) content of the oil;iii.Relative stability of some active oils (to heat, ageing at room temperature);iv.The… 
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It is indicated that topical emu oil has anti-inflammatory properties in the CD-1 mouse that are associated with decreased auricular thickness and weight, and with the cytokines IL-1α and TNF-α.
Emu oil offers protection in Crohn’s disease model in rats
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Review on emu products for use as complementary and alternative medicine.
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Emu Oil: A novel therapeutic for disorders of the gastrointestinal tract?
Emu Oil has been demonstrated to endow partial protection against chemotherapy‐induced mucositis, with early indications of improved intestinal repair, and could form the basis of an adjunct to conventional treatment approaches for inflammatory disorders affecting the gastrointestinal system.
Comparison of the antioxidant properties of emu oil with other avian oils
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Emu oil decreased acute ileal inflammation, and improved mucosal architecture in the intestine during recovery from chemotherapy in rats, and the potential benefits of emu oil as a nutritional supplement for the treatment of intestinal disorders are indicated.
Emu Oil Reduces Small Intestinal Inflammation in the Absence of Clinical Improvement in a Rat Model of Indomethacin-Induced Enteropathy
EO reduced acute intestinal inflammation, whereas other parameters of Indomethacin-induced intestinal injury were not affected significantly, and increased EO dose and/or frequency of administration could potentially improve clinical efficacy.
Over the counter (OTC) oral remedies for arthritis and rheumatism: how effective are they?
Quality control is urgently needed to justify the veracity of manufacturers’ claims permitted by the Therapeutic Goods Administration in Australia for a range of self-medication products to treat the pain and inflammation of arthritis, available in local pharmacies, supermarkets or by mail order.


Anti-inflammatory activity of emu oils in rats
Four of the preparations of emu oil were found to be active against adjuvant-induced arthritis in rats, and the efficacies of the emu oils acting transdermally are compared with that of orally administered ibuprofen.
Prevention of adjuvant‐induced cachexia in rats by cyclosporin A
The results are consistent with CS preventing the release of cytokines which have anorectic and catabolic actions (IL‐1, TNF), although there is also the possibility that CS has effects involving endocrine mechanisms.