Emt/Itk associates with activated TCR complexes: role of the pleckstrin homology domain.

@article{Ching1999EmtItkAW,
  title={Emt/Itk associates with activated TCR complexes: role of the pleckstrin homology domain.},
  author={Keith A. Ching and Yuko Kawakami and Toshiaki Kawakami and Constantine D. Tsoukas},
  journal={Journal of immunology},
  year={1999},
  volume={163 11},
  pages={6006-13}
}
Expressed in mast and T-cells/inducible T cell tyrosine kinase (Emt/Itk) is a protein tyrosine kinase required for T cell Ag receptor (TCR)-induced activation and development. A physical interaction between Emt/Itk and TCR has not been described previously. Here, we have utilized laser scanning confocal microscopy to demonstrate that Ab-mediated engagement of the CD3epsilon chain induces the membrane colocalization of Emt/Itk with TCR/CD3. Removal of the Emt/Itk pleckstrin homology domain… CONTINUE READING
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