Empty spiracles is required for the development of olfactory projection neuron circuitry in Drosophila.

@article{Lichtneckert2008EmptySI,
  title={Empty spiracles is required for the development of olfactory projection neuron circuitry in Drosophila.},
  author={Robert Lichtneckert and Lionel Nobs and Heinrich Reichert},
  journal={Development},
  year={2008},
  volume={135 14},
  pages={2415-24}
}
In both insects and mammals, second-order olfactory neurons receive input from olfactory receptor neurons and relay olfactory input to higher brain centers. In Drosophila, the wiring specificity of these olfactory projection neurons (PNs) is predetermined by their lineage identity and birth order. However, the genetic programs that control this wiring specificity are not well understood. The cephalic gap gene empty spiracles (ems) encodes a homeodomain transcription factor required for… CONTINUE READING
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