Employment of the Epidermal Growth Factor Receptor in Growth Factor–Independent Signaling Pathways

@article{Carpenter1999EmploymentOT,
  title={Employment of the Epidermal Growth Factor Receptor in Growth Factor–Independent Signaling Pathways},
  author={Graham F Carpenter},
  journal={The Journal of Cell Biology},
  year={1999},
  volume={146},
  pages={697 - 702}
}
T HE traditional view of growth factor receptors and hormone receptors in general is that a specific ligand directly recognizes a highly selective binding site on its cognate receptor and, thereby, activates receptor-dependent signaling and biological responses. In the case of the EGF receptor, several structurally related proteins (EGF, transforming growth… CONTINUE READING