Employment of the Epidermal Growth Factor Receptor in Growth Factor–Independent Signaling Pathways

@article{Carpenter1999EmploymentOT,
  title={Employment of the Epidermal Growth Factor Receptor in Growth Factor–Independent Signaling Pathways},
  author={G. Carpenter},
  journal={The Journal of Cell Biology},
  year={1999},
  volume={146},
  pages={697 - 702}
}
  • G. Carpenter
  • Published 1999
  • Biology, Medicine
  • The Journal of Cell Biology
The traditional view of growth factor receptors and hormone receptors in general is that a specific ligand directly recognizes a highly selective binding site on its cognate receptor and, thereby, activates receptor-dependent signaling and biological responses. In the case of the EGF receptor, several structurally related proteins (EGF, transforming growth factor alpha, amphiregulin, betacellulin, epiregulin, heparin-binding EGF) are recognized as direct agonists. Each of these growth factors… Expand
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