Employing pancreatic tumor γ-glutamyltransferase for therapeutic delivery.

  title={Employing pancreatic tumor γ-glutamyltransferase for therapeutic delivery.},
  author={Emma E. Ramsay and St{\'e}phanie Decollogne and Swapna Joshi and Alessandro Corti and Minoti Vivek Apte and Alfonso Pompella and Philip J Hogg and Pierre J. Dilda},
  journal={Molecular pharmaceutics},
  volume={11 5},
γ-Glutamyltransferase (γGT) is a cell surface enzyme that catalyzes hydrolysis of the bond linking the glutamate and cysteine residues of glutathione and glutathione-S-conjugates. We have observed that human pancreatic tumor cells and tumor-associated stellate cells express high levels of this enzyme when compared to normal pancreatic epithelial and stellate cells. Detection of the protein in tumor sections correlated with γGT activity on the surface of the cultured tumor and stellate cells. We… CONTINUE READING


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