Empirically derived criteria cast doubt on the clinical significance of antidepressant-placebo differences.


Meta-analyses indicate that antidepressants are superior to placebos in statistical terms, but the clinical relevance of the differences has not been established. Previous suggestions of clinically relevant effect sizes have not been supported by empirical evidence. In the current paper we apply an empirical method that consists of comparing scores obtained… (More)
DOI: 10.1016/j.cct.2015.05.005


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