Empirical therapy for uncomplicated urinary tract infections in an era of increasing antimicrobial resistance: a decision and cost analysis.

@article{Le2001EmpiricalTF,
  title={Empirical therapy for uncomplicated urinary tract infections in an era of increasing antimicrobial resistance: a decision and cost analysis.},
  author={Thuan P. Le and Loren G. Miller},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2001},
  volume={33 5},
  pages={
          615-21
        }
}
Infectious Diseases Society of America guidelines state that uncomplicated urinary tract infections (UTIs) should be treated empirically with trimethoprim-sulfamethoxazole (TMP-SMZ), unless the community resistance among uropathogens exceeds 10%-20%, in which case a fluoroquinolone (FQ) should be used. However, the data to support this threshold are limited. We performed a cost-minimization and sensitivity analysis to determine what level of TMP-SMZ resistance in a community should trigger FQ… CONTINUE READING

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