Empirical study on chemotherapeutic susceptibility of SP cells in human pulmonary adenocarcinoma cell line A549 in Vitro

@article{Xie2010EmpiricalSO,
  title={Empirical study on chemotherapeutic susceptibility of SP cells in human pulmonary adenocarcinoma cell line A549 in Vitro},
  author={Tong Xie and Li Li and D. Liu and Naiquan Mao and Danrong Li and Chuantian Zuo and Dingming Huang},
  journal={Clinical Oncology and Cancer Research},
  year={2010},
  volume={7},
  pages={265-270}
}
ObjectiveTo explore the chemotherapeutic susceptibility of SP cells in human pulmonary adenocarcinoma cell line A549 and the possible mechanism of multidrug resistanceMethodsSP and non-SP (NSP) cells in the cell line A549 were isolated by fluorescence activated cell sorter. The susceptibility of SP and NSP cells to DDP, 5-FU, VP16, NVB and GEM was detected by a drug susceptibility test, and IC50s were calculated 24 h after the chemotherapy; and then after a 2-hour IC50 treatment with 5… CONTINUE READING

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