Empirical fitness landscapes reveal accessible evolutionary paths

@article{Poelwijk2007EmpiricalFL,
  title={Empirical fitness landscapes reveal accessible evolutionary paths},
  author={F. J. Poelwijk and D. J. Kiviet and D. Weinreich and S. Tans},
  journal={Nature},
  year={2007},
  volume={445},
  pages={383-386}
}
  • F. J. Poelwijk, D. J. Kiviet, +1 author S. Tans
  • Published 2007
  • Biology, Medicine
  • Nature
  • When attempting to understand evolution, we traditionally rely on analysing evolutionary outcomes, despite the fact that unseen intermediates determine its course. A handful of recent studies has begun to explore these intermediate evolutionary forms, which can be reconstructed in the laboratory. With this first view on empirical evolutionary landscapes, we can now finally start asking why particular evolutionary paths are taken. 
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    References

    SHOWING 1-10 OF 40 REFERENCES
    Metastable evolutionary dynamics: Crossing fitness barriers or escaping via neutral paths?
    • 125
    • PDF
    Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations.
    • R. Lenski, M. Travisano
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1994
    • 846
    • PDF
    Resurrecting ancient genes: experimental analysis of extinct molecules
    • J. Thornton
    • Biology, Medicine
    • Nature Reviews Genetics
    • 2004
    • 269
    • PDF