• DOI:10.1001/JAMA.273.5.408
Corpus ID: 12920412

Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials.

@article{Schulz1995EmpiricalEO,
  title={Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials.},
  author={K. Schulz and I. Chalmers and R. Hayes and D. Altman},
  journal={JAMA},
  year={1995},
  volume={273 5},
  pages={
          408-12
        }
}

K. Schulz, I. Chalmers, +1 author D. Altman

Published 1995

Medicine

JAMA

OBJECTIVE To determine if inadequate approaches to randomized controlled trial design and execution are associated with evidence of bias in estimating treatment effects. DESIGN An observational study in which we assessed the methodological quality of 250 controlled trials from 33 meta-analyses and then analyzed, using multiple logistic regression models, the associations between those assessments and estimated treatment effects. DATA SOURCES Meta-analyses from the Cochrane Pregnancy and… CONTINUE READING

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