Empirical and computational design of iron-sulfur cluster proteins.

  title={Empirical and computational design of iron-sulfur cluster proteins.},
  author={Joanna M Grzyb and Fei Xu and Vikas Nanda and Renata Luczkowska and Eduard J. Reijerse and Wolfgang Lubitz and Dror Noy},
  journal={Biochimica et biophysica acta},
  volume={1817 8},
Here, we compare two approaches of protein design. A computational approach was used in the design of the coiled-coil iron-sulfur protein, CCIS, as a four helix bundle binding an iron-sulfur cluster within its hydrophobic core. An empirical approach was used for designing the redox-chain maquette, RCM as a four-helix bundle assembling iron-sulfur clusters… CONTINUE READING