Empirical Valence Bond Simulations of the Hydride-Transfer Step in the Monoamine Oxidase A Catalyzed Metabolism of Noradrenaline.

@article{Pobernik2016EmpiricalVB,
  title={Empirical Valence Bond Simulations of the Hydride-Transfer Step in the Monoamine Oxidase A Catalyzed Metabolism of Noradrenaline.},
  author={Matic Pober{\vz}nik and Miha Purg and Matej Repi{\vc} and Janez Mavri and Robert Vianello},
  journal={The journal of physical chemistry. B},
  year={2016},
  volume={120 44},
  pages={
          11419-11427
        }
}
Monoamine oxidases (MAOs) A and B are flavoenzymes responsible for the metabolism of biogenic amines, such as dopamine, serotonin, and noradrenaline (NA), which is why they have been extensively implicated in the etiology and course of various neurodegenerative disorders and, accordingly, used as primary pharmacological targets to treat these debilitating cognitive diseases. The precise chemical mechanism through which MAOs regulate the amine concentration, which is vital for the development of… CONTINUE READING
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