Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida Colonization, and Multiple Organ Failure: The EMPIRICUS Randomized Clinical Trial.

@article{Timsit2016EmpiricalMT,
  title={Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida Colonization, and Multiple Organ Failure: The EMPIRICUS Randomized Clinical Trial.},
  author={Jean-François Timsit and Elie Azoulay and Carole Schwebel and Pierre-Emmanuel Charles and Murielle Cornet and Bertrand Souweine and Kada Klouche and Bertrand L. Jaber and Jean Louis Trouillet and Fabrice Bruneel and Laurent Argaud and Jo{\"e}l Cousson and Ferhat Meziani and Didier Gruson and Adeline Paris and Michael Darmon and Ma{\"i}t{\'e} Garrouste-Orgeas and Jean Christophe Navellou and Arnaud Foucrier and Bernard Allaouchiche and V. Kesava Das and J. P. Gangneux and St{\'e}phane Ruckly and Dani{\'e}le Maubon and Vincent Jullien and Michel M. Wolff},
  journal={JAMA},
  year={2016},
  volume={316 15},
  pages={
          1555-1564
        }
}
Importance Although frequently used in treating intensive care unit (ICU) patients with sepsis, empirical antifungal therapy, initiated for suspected fungal infection, has not been shown to improve outcome. Objective To determine whether empirical micafungin reduces invasive fungal infection (IFI)-free survival at day 28. Design, Setting, and Participants Multicenter double-blind placebo-controlled study of 260 nonneutropenic, nontransplanted, critically ill patients with ICU-acquired… CONTINUE READING
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Assessment of preemptive treatment to prevent Empirical Micafungin Treatment and Invasive Fungal Infection–Free Survival Original Investigation Research jama.com (Reprinted

  • R Piarroux, F Grenouillet, P Balvay
  • JAMA October
  • 2016

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