Empiric risk of prostate carcinoma for relatives of patients with prostate carcinoma

  title={Empiric risk of prostate carcinoma for relatives of patients with prostate carcinoma},
  author={Maurice P. A. Zeegers and Anne Jellema and Harry Ostrer},
Although narrative reviews have concluded that there is strong support for familial clustering of prostate carcinoma, the association has never systematically been quantified in reviews. The purpose of this meta–analysis was to summarize and quantify the recurrence risk ratio with emphasis on the degree of relation, the specific relationship of the family member, the number of affected family members, and the age at diagnosis. 

Risk of invasive prostate cancer and prostate cancer death in relatives of patients with prostatic borderline or in situ neoplasia: A nationwide cohort study

The objective of the current study was to provide an evidence‐based risk estimation for the relatives of patients with PBISN.

Genetic etiology of hereditary prostate cancer.

This chapter will review family-based genetic linkage analyses for PC, describe the challenges of this endeavor, and describe efforts to confront these challenges, such as using larger sets of families and more homogeneous subgroups.

Identification of Genetic Risk Factors for Prostate Cancer: Analytic Approaches Using Hereditary Prostate Cancer Families

In 2009, prostate cancer is the most commonly diagnosed nonskin cancer among men in the United States, and a leading cause of cancer-related mortality, with an estimated 27,360 related deaths.

Early onset prostate cancer has a significant genetic component

Prostate cancer affects more than 190,000 men each year with ∼10% of men diagnosed at ≤55 years, that is, early onset (EO) PCa, likely reflects a stronger underlying genetic etiology.

Etiology of prostate cancer ( C 61 ) in Central and South America

Modifiable factors such as obesity, physical inactivity, and dietary factors are focused on to identify opportunities for prevention and research in the Central and South American region.

Risk perception and concern among brothers of men with prostate carcinoma

It is important for clinicians, researchers, and others who shape public health policy to understand the demographic correlates and psychologic factors that drive health behaviors, such as screening

Tumour Genetics (Prostate/Testis/Penis)

A family history is a major risk factor for prostate cancer and brothers of men with testis cancer have an eight- to tenfold risk themselves oftestis cancer.

Genetics of prostate cancer risk.

With the sequencing of the human genome and the completion of the initial phases of the International HapMap Project, the tools are available to scan the entire genome and find genetic markers for disease.

Clinicopathological characteristics of localized prostate cancer in younger men aged ≤ 50 years treated with radical prostatectomy in the PSA era: A systematic review and meta‐analysis

With the rapid increase in younger age prostate cancer (PCa) patients, the impact of younger age on decision‐making for PCa treatment needs to be revaluated in the new era.

Young-age prostate cancer

An update on the most recent findings in young-age prostate cancer, including a number of susceptibility genes such as BRCA2 and HOXB13 were reported, each with their own specific biological and histopathology features.



[Familial aspects of prostatic carcinoma. Personal experience and review of the literature].

In this anamnestic-type survey of two sample groups, one with prostate carcinoma and the other a control group, the authors attempt to make a general confirmation of the assertions made by other authors on the increased risk that brothers and sons of patients with this disease might be affected by prostate carcinomas.

Familial prostate cancer in sweden: A nationwide register cohort study

A population‐based cohort study was performed, that attempted to avoid possible bias connected with some earlier studies of familial prostate cancer.

Age specific and attributable risks of familial prostate carcinoma from the family‐cancer database

Familial risks by proband status and age are useful for clinical counseling, and they can be used to calculate population‐attributable fractions (PAFs), which show the proportion of disease that

Heredity and prostate cancer: A study of World War II veteran twins

Increased risk of prostate cancer among men with a family history of the disease has been observed in several epidemiological studies, and family studies have identified hereditary prostate cancer

Familial risk factors for prostate cancer.

A complex segregation analysis of the 691 prostate cancer families showed that prostate cancer clustering can be explained by Mendelian inheritance of a rare autosomal gene producing prostate cancer at an early age.

A case-cohort study on prostate cancer risk in relation to family history of prostate cancer.

The associations the authors observed were stronger for cases diagnosed before age 70 compared with cases diagnosed after age 70 and for advanced compared with localized tumors.

Genetic characteristics of prostate cancer.

  • M. HuncharekJ. Muscat
  • Medicine, Biology
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 1995
Current available evidence regarding the genetic characteristics of adenocarcinoma of the prostate is reviewed, including the impact of family history of disease risk, the nature of structural genetic aberrations, and the possible role of oncogenes and tumor suppressor genes in its pathogenesis.

Epidemiology of prostatic cancer: A case‐control study

A population‐based case‐control study of prostatic cancer in Alberta was undertaken to determine the risk factors associated with the disease. Cases were 382 newly diagnosed prostatic cancer patients

Hereditary aspects of prostate cancer.

  • D. L. McLellanR. Norman
  • Medicine
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
  • 1995
Recent confirmation of the familial clustering and Mendelian inheritance patterns of some prostate cancer has important implications and increases the potential for directed research into the causes of prostate cancer and for refinements in the current screening practices to detect this common disease.