Empiric combination antibiotic therapy is associated with improved outcome against sepsis due to Gram-negative bacteria: a retrospective analysis.

@article{Micek2010EmpiricCA,
  title={Empiric combination antibiotic therapy is associated with improved outcome against sepsis due to Gram-negative bacteria: a retrospective analysis.},
  author={Scott T. Micek and Emily C Welch and Junaid I Khan and Mubashir Pervez and Joshua A. Doherty and Richard M. Reichley and Marin H Kollef},
  journal={Antimicrobial agents and chemotherapy},
  year={2010},
  volume={54 5},
  pages={1742-8}
}
The optimal approach for empirical antibiotic therapy in patients with severe sepsis and septic shock remains controversial. A retrospective cohort study was conducted in the intensive care units of a university hospital. The data from 760 patients with severe sepsis or septic shock associated with Gram-negative bacteremia was analyzed. Among this cohort, 238 (31.3%) patients received inappropriate initial antimicrobial therapy (IIAT). The hospital mortality rate was statistically greater among… CONTINUE READING

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