Emotional stress induces transient left ventricular hypocontraction in the rat via activation of cardiac adrenoceptors: a possible animal model of 'tako-tsubo' cardiomyopathy.

@article{Ueyama2002EmotionalSI,
  title={Emotional stress induces transient left ventricular hypocontraction in the rat via activation of cardiac adrenoceptors: a possible animal model of 'tako-tsubo' cardiomyopathy.},
  author={Takashi Ueyama and Ken Kasamatsu and Takuzo Hano and Katsuhiro Yamamoto and Yoshihiro Tsuruo and Ichiro Nishio},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  year={2002},
  volume={66 7},
  pages={712-3}
}
The etiology of a novel cardiac syndrome 'tako-tsubo' cardiomyopathy, otherwise known as 'transient left ventricular (LV) apical ballooning' and which mimics acute myocardial infarction, is not clear; however, emotional or physical stress is known to precede the attack. Left ventriculography of rats experiencing emotional stress induced reversible LV apical ballooning, which was normalized by pretreatment with adrenoceptor blockade. Together with results of previous studies, activation of… CONTINUE READING