Emotional stress induces immediate-early gene expression in rat heart via activation of alpha- and beta-adrenoceptors.

@article{Ueyama1999EmotionalSI,
  title={Emotional stress induces immediate-early gene expression in rat heart via activation of alpha- and beta-adrenoceptors.},
  author={Takashi Ueyama and Ken-ichi Yoshida and Emiko Senba},
  journal={The American journal of physiology},
  year={1999},
  volume={277 4 Pt 2},
  pages={H1553-61}
}
We have studied the adrenergic mechanisms of immediate-early gene (IEG) induction in the discrete types of cardiac cells with the use of in situ hybridization histochemistry in an immobilization-stress model in conscious rats. Expression of c-fos, fos B, c-jun, jun B, NGFI-A, and NGFI-B mRNA was rapidly upregulated in the endothelial, myocardial, and smooth muscle cells of coronary vessels by 15-45 min after the onset of immobilization. Simultaneous blockade of both alpha- and beta… CONTINUE READING