Emotional arousal enhances declarative memory in patients with Alzheimer’s disease

  title={Emotional arousal enhances declarative memory in patients with Alzheimer’s disease},
  author={Corina Satler and L. Medina Garrido and Emanuel Sarmiento and Sabrina P Leme and Carlos Conde and Carlos Tomaz},
  journal={Acta Neurologica Scandinavica},
Objective –  To verify whether the long‐term retention of an emotionally arousing story is stronger than the retention of a neutral story, and the enhancing effects of emotional arousal on declarative memory in Alzheimer’s disease (AD) patients. 

Preserved and Impaired Emotional Memory in Alzheimer’s Disease

It is argued that the EEE could be a useful paradigm to reduce impairment in episodic memory tasks, according to which a compensatory mechanism in patients with AD solicits greater amygdala functioning or additional networks, even when amygdala atrophy is present.

Emotional Working Memory in Alzheimer's Disease Patients

  • C. SatlerC. Tomaz
  • Psychology, Medicine
    Dementia and Geriatric Cognitive Disorders Extra
  • 2011
The results suggest that AD patients show a relative preservation of working memory for emotional information, particularly for negative stimuli.

The Impact of Aging and Alzheimer's Disease on Emotional Enhancement of Memory

The impaired Eem for verbal and preserved EEM for non-verbal declarative memory in patients with AD are highlighted, the neurobiological underpinnings of which should be addressed by future studies.

Emotion Processing for Arousal and Neutral Content in Alzheimer's Disease

AD patients show changes in emotional processing on declarative memory and a preserved ability to express emotions in face of arousal content and the present findings suggest that these impairments are due to general cognitive decline.

Emotional Valence Affects Word Retrieval During Verb Fluency Tasks in Alzheimer’s Dementia

Individuals with amnestic Alzheimer’s disease (AD) often demonstrate preserved emotional processing skills despite the neurodegenerative disease that affects their limbic system. Emotional valence

Impaired emotional autobiographical memory associated with right amygdalar-hippocampal atrophy in Alzheimer’s disease patients

Overall, AD patients displayed a deficit in emotional AbM as they elicited less emotional memories than the controls, however, the specificity of those memories was preserved, and emotional memories were more specific than neutral memories in both groups, reflecting an enhancement effect of emotion that could be supported by other brain regions that are spared during the early stages of the disease.

Emotional Reactivity to Film Material in Alzheimer’s Disease

The AD patients showed reduced self-reported reactivity to negative films, but exhibited a pattern of facial responses similar to controls for all films, suggesting that awareness may mediate responses to dementia-related material.

dans la maladie d'Alzheimer et le vieillissement normal Emotional memory enhancement in Alzheimer's disease and normal aging

There is much evidence that EEM remains intact across lifespan, and one possible explanation for the absence of emotional memory enhancement in Alzheimer's disease is the disruption of the modulation of encoding and consolidation processes typically elicited by emotion.



Enhancement of declarative memory by emotional arousal and visual memory function in Alzheimer's disease.

In AD, memory enhancement by emotion was significantly correlated with visual memory but not with verbal memory, regardless of age, sex, educational attainment, and severity of dementia, suggesting a close association between memory enhancementBy emotion and visual memory.

Memory for emotional stimuli in patients with Alzheimer's disease

Findings of improved immediate memory for emotional material in AD lends support to the notion that mnemonic functions are differentially affected in the disease.

Impact of emotion on memory. Controlled study of the influence of emotionally charged material on declarative memory in Alzheimer's disease.

  • H. KazuiE. Mori L. Cahill
  • Psychology, Medicine
    The British journal of psychiatry : the journal of mental science
  • 2000
Evidence is provided that emotional arousal enhances declarative memory in patients with Alzheimer's disease, and a clue to the management of people with dementia is given.

Processing Emotional Information in Alzheimer’s Disease: Effects on Memory Performance and Neurophysiological Correlates

The results show relatively preserved emotional processing in patients with AD and suggest that the emotional content of a context can influence memory performance, although there is no evidence that this effect is mediated by attention as measured by ERP.

Effects of normal aging and Alzheimer's disease on emotional memory.

Young and older adults, but not AD patients, showed better memory for emotional versus neutral pictures and words, whereas young adults remembered more items embedded in an emotional versusneutral context.

Effects of Alzheimer disease on memory for verbal emotional information

Amygdalar volume and emotional memory in Alzheimer's disease.

Irrespective of generalized brain atrophy and cognitive impairments, emotional memory was correlated more with normalized amygdalar volume (right and left averaged) than with normalized hippocampal volume, and evidence of the amygdala's involvement in emotional memory in humans is provided.

Impaired declarative memory for emotional material following bilateral amygdala damage in humans.

The data support the hypothesis that the human amygdala normally enhances acquisition of declarative knowledge regarding emotionally arousing stimuli and that nondeclarative emotional memory in humans is impaired by lesions of the amygdala.

Amnestic people with Alzheimer's disease who remembered the Kobe earthquake

Fear reinforces memory retention of an episode in subjects with Alzheimer's disease but does not enhance retention of its context, despite repeated exposure to the information.

Lateralized impairment of the emotional enhancement of verbal memory in patients with amygdala–hippocampus lesion