Emotional Lability, Intrusiveness, and Catastrophic Reactions

@article{Haupt1997EmotionalLI,
  title={Emotional Lability, Intrusiveness, and Catastrophic Reactions},
  author={Martin Haupt},
  journal={International Psychogeriatrics},
  year={1997},
  volume={8},
  pages={409 - 414}
}
  • M. Haupt
  • Published 1 May 1997
  • Psychology, Medicine
  • International Psychogeriatrics
Emotional lability, intrusiveness, and catastrophic reactions are some of the noncognitive psychopathologic phenomena seen in patients with Alzheimer's disease. These symptoms occur frequently throughout the disease course and strongly influence the well-being of patients with dementia and their caregivers. 

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The feasibility and usefulness of subtyping aggressive and agitated symptoms in patients with dementia according to whether these behaviors occur spontaneously or in response to environmental factors is considered.

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Review of pseudobulbar affect including a novel and potential therapy.

  • R. SchifferL. Pope
  • Psychology, Medicine
    The Journal of neuropsychiatry and clinical neurosciences
  • 2005
Evidence suggests that treatment with a fixed combination of dextromethorphan and the cytochrome P450 2D6 enzyme inhibitor, quinidine, can improve PBA.

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The overall prevalence of PBA was estimated to be about 10% across these commonly associated underlying neurological conditions and appears to be under-recognized.

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Pseudobulbar affect: prevalence and quality of life impact in movement disorders

A validated self-administered screening instrument, the Center for Neurologic Study-Lability Scale (CNS-LS), was used to study the prevalence of PBA, its association with mood symptoms, and the quality of life impact and found patients with PBA tend to have more depressive symptoms and poorerquality of life.

Pathological Laughing and Crying

SSRIs are recommended as first-line pharmacotherapy for this disorder and other treatment options, including TCAs, noradrenergic reuptake inhibitors, novel antidepressants, dopaminergic agents and uncompetitive NMDA receptor antagonists may be useful second-line treatments.

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Requests for offprints should be directed to Martin Haupt

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