Emotion regulation: Quantitative meta-analysis of functional activation and deactivation

  title={Emotion regulation: Quantitative meta-analysis of functional activation and deactivation},
  author={David W. Frank and Matthew Dewitt and Matthew E Hudgens-Haney and David J. Schaeffer and B. Hunter Ball and Nicolette Francoise Schwarz and Anan A. Hussein and Laura M. Smart and Dean Sabatinelli},
  journal={Neuroscience \& Biobehavioral Reviews},

Neural representation of emotion regulation goals

The neural mechanisms of regulating emotion using fMRI are examined and a core system that represents reappraisal goals in an abstract, stimulus‐independent fashion is identified, concluding that those cognitive mechanisms may be used for orchestrating emotion regulation.

Brain activation during cognitive reappraisal depending on regulation goals and stimulus valence

Reappraisal is not a uniform process and may have different neural bases depending on regulation goals and stimulus valence, as well as differences in brain activation between the ‘decrease’ and ‘ increase’ emotional response conditions.

Imaging the up’s and down’s of emotion regulation in lifetime depression

Despite a pattern of reduced neural emotional reactivity in mainly medicated patients, their ‘successful’ recruitment of the regulation network for up-regulation might point toward an effective use of reappraisal when increasing negative emotions.

The neural bases of cognitive emotion regulation: The roles of strategy and intensity

Findings indicated that prefrontal regions were engaged by all three regulation strategies, but reappraisal showed the least amount of increase in activity as a function of intensity, consistent with the notion that there is a continuum of cognitive emotion regulation along which all three of these strategies lie.

Effective amygdala-prefrontal connectivity predicts individual differences in successful emotion regulation

It is suggested that successful reappraisal is linked to changes in effective connectivity between two systems, prefrontal cognitive control regions and regions crucially involved in emotional evaluation.

Successful Emotion Regulation Is Predicted by Amygdala Activity and Aspects of Personality: A Latent Variable Approach

It is found that successful downregulation is predicted by activity in key regions related to emotion processing, and the individual ability to successfully upregulate emotions is strongly associated with the ability to identify feelings, conscientiousness, and neuroticism.

The Role of Motivation in Cognitive Reappraisal for Depressed Patients

The findings highlight the modulatory role of approach and avoidance motivation in cognitive reappraisal, which is dysfunctional in depressed patients and could enlighten the CBT directed at modifying the motivation deficits in cognitive regulation of emotion.

Emotion suppression failures are associated with local increases in sleep-like activity

The results indicate that local sleep-like activity may represent the cause of emotion suppression failures in humans, and may offer a functional explanation for previous observations linking lack of sleep, changes in frontal activity and emotional dysregulation.



Regulation of emotional responses elicited by threat‐related stimuli

It is demonstrated that amygdala responses to threat‐related stimuli can be controlled through the use of cognitive strategies depending on recruitment of prefrontal areas, thereby changing the subject's affective state.

Amygdala-frontal connectivity during emotion regulation.

It is shown that activity in specific areas of the frontal cortex covaries with amygdala activity and that this functional connectivity is dependent on the reappraisal task, highlighting the importance of functional connectivity within limbic-frontal circuitry during emotion regulation.

Neural Correlates of Positive and Negative Emotion Regulation

Increasing and decreasing positive and negative emotion can thus increase and decrease subjective reactions and associated amygdala activity in line with regulatory goals, and is associated with different patterns of prefrontal activation as a function of emotional valence and regulatory goal.

Prefrontal Control of the Amygdala during Real-Time fMRI Neurofeedback Training of Emotion Regulation

An exploratory analysis provides insights into the causal relationships within the network of regions engaged during the rTFMRI-nf procedure targeting the amygdala, suggesting that the rACC may constitute a promising target for rtfMRI- nf training along with the amygdala in patients with affective disorders, particularly posttraumatic stress disorder (PTSD).

Rethinking Feelings: An fMRI Study of the Cognitive Regulation of Emotion

Functional magnetic resonance imaging findings support the hypothesis that prefrontal cortex is involved in constructing reappraisal strategies that can modulate activity in multiple emotion-processing systems.