Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits delta8-delta7 sterol isomerase activity in yeast.

@article{Silve1996EmopamilbindingPA,
  title={Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits delta8-delta7 sterol isomerase activity in yeast.},
  author={Sandra Silve and Pierre Dupuy and C Labit-Lebouteiller and Mourad Kaghad and Pascale Chalon and Alain Rahier and Maryse Taton and Jan Lupker and David Shire and G{\'e}rard Loison},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 37},
  pages={22434-40}
}
Delta8-delta7 sterol isomerase is an essential enzyme on the sterol biosynthesis pathway in eukaryotes. This endoplasmic reticulum-resident membrane protein catalyzes the conversion of delta8-sterols to their corresponding delta7-isomers. No sequence data for high eukaryote sterol isomerase being available so far, we have cloned a murine sterol isomerase… CONTINUE READING