Emodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy

  title={Emodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy},
  author={Nianxiu Tian and Yanbin Gao and X. Wang and Xiaoming Wu and D. Zou and Z. Zhu and Zheji Han and T. Wang and Yimin Shi},
  journal={Drug Design, Development and Therapy},
  pages={2195 - 2211}
  • Nianxiu Tian, Yanbin Gao, +6 authors Yimin Shi
  • Published 2018
  • Chemistry, Medicine
  • Drug Design, Development and Therapy
  • Background Endoplasmic reticulum stress is associated with podocyte apoptosis in the pathogenesis of diabetic nephropathy (DN). A previous study has demonstrated that emodin has a protective effect in the kidney by suppressing proliferation of mesangial cells and inhibiting the renal tubular epithelial-to-mesenchymal transition. However, the effects of emodin on the podocyte apoptosis in DN and its mechanisms are unknown. Aim This study aimed to explore the effect of emodin on DN model KK-Ay… CONTINUE READING
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