Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway

@article{Huang2005EmodinIT,
  title={Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway},
  author={Qingrong Huang and Huawen Shen and Chin Kin Ong},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2005},
  volume={62},
  pages={1167-1175}
}
Enhanced cell migration is one of the underlying mechanisms in cancer invasion and metastasis. Therefore, inhibition of cell migration is considered to be an effective strategy for prevention of cancer metastasis. We found that emodin (3-methyl-1,6,8-trihydroxyanthraquinone), an active component from the rhizome of Rheum palmatum, significantly inhibited epidermal growth factor (EGF)- induced migration in various human cancer cell lines. In the search for the underlying molecular mechanisms, we… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 41 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

Inhibitory effect of emodin on tumor invasion through suppression of activator protein - 1 and nuclear factor - kappaB

  • Q. Huang, M. ShenH., N. OngC.
  • Biochem . Pharmacol .
  • 2004

Activation of the PI 3 K / Akt pathway and chemotherapeutic resistance

  • A. WestK., S. CastilloS., A. DennisP.
  • Drug Resist . Update
  • 2002

Similar Papers

Loading similar papers…