Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3.

@article{Subramaniam2013EmodinIG,
  title={Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3.},
  author={Aruljothi Subramaniam and Muthu Kumaraswamy Shanmugam and Tina H. Ong and Feng Li and Ekambaram Perumal and Luxi Chen and Shireen Vali and Taher Abbasi and Shweta Kapoor and Kwang Seok Ahn and Alan Prem Kumar and Kam Man Hui and Gautam Sethi},
  journal={British journal of pharmacology},
  year={2013},
  volume={170 4},
  pages={807-21}
}
BACKGROUND AND PURPOSE Aberrant activation of STAT3 is frequently encountered and promotes proliferation, survival, metastasis and angiogenesis in hepatocellular carcinoma (HCC). Here, we have investigated whether emodin mediates its effect through interference with the STAT3 activation pathway in HCC. EXPERIMENTAL APPROACH The effect of emodin on STAT3 activation, associated protein kinases and apoptosis was investigated using various HCC cell lines. Additionally, we also used a predictive… CONTINUE READING
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