Emodin has cytotoxic and protective effects in rat C6 glioma cells: roles of Mdr1a and nuclear factor kappaB in cell survival.

@article{Kuo2009EmodinHC,
  title={Emodin has cytotoxic and protective effects in rat C6 glioma cells: roles of Mdr1a and nuclear factor kappaB in cell survival.},
  author={Tzu-Ching Kuo and J. Yang and M Lin and Shu-Chun Hsu and J Lin and Hui-Ju Lin and Te-chun Hsia and Ching-Lung Liao and M Yang and Ming-Jen Fan and Wellington Gibson Wood and Jing-Gung Chung},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={330 3},
  pages={736-44}
}
1,3,8-Trihydroxy-6-methylanthaquinone (emodin) is recognized as an antiproliferative compound. In the present study, however, we show that emodin has both toxic and survival effects in glioma cells and that the survival effects involve Mdr1a. Emodin inhibited the proliferation and induced apoptosis of C6 cells in a 12-h treatment, but C6 cells survived a 72-h drug treatment, indicating resistance to emodin. Emodin-induced apoptosis was reduced by inhibition of the expression and activation of… CONTINUE READING