Emodin ameliorates high-fat-diet induced insulin resistance in rats by reducing lipid accumulation in skeletal muscle.

@article{Cao2016EmodinAH,
  title={Emodin ameliorates high-fat-diet induced insulin resistance in rats by reducing lipid accumulation in skeletal muscle.},
  author={Yanni Cao and Shufang Chang and Jie Dong and Shenyin Zhu and Xiaoying Zheng and Juan Li and Rui Jun Long and Yuanda Zhou and Jianyu Cui and Yingjie Zhang},
  journal={European journal of pharmacology},
  year={2016},
  volume={780},
  pages={
          194-201
        }
}
Emodin, an anthraquinone derivative isolated from root and rhizome of Rheum palmatum, has been reported to have promising anti-diabetic activity. The present study was to explore the possible mechanism of emodin to ameliorate insulin resistance. Insulin resistance was induced by feeding a high fat diet to Sprague-Dawley rats. The blood glucose and lipid profiles in serum were measured by an enzymatic method, and a hyperinsulinaemic-euglycaemic clamp was used to evaluate insulin resistance. L6… CONTINUE READING
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