Emodin Suppresses Hyperglycemia-Induced Proliferation and Fibronectin Expression in Mesangial Cells via Inhibiting cFLIP

  title={Emodin Suppresses Hyperglycemia-Induced Proliferation and Fibronectin Expression in Mesangial Cells via Inhibiting cFLIP},
  author={J. Gao and Fangli Wang and Weisong Wang and Zhiguo Su and Canghui Guo and Shuyi Cao},
  journal={PLoS ONE},
  • J. Gao, Fangli Wang, +3 authors Shuyi Cao
  • Published 2014
  • Biology, Medicine
  • PLoS ONE
  • As one of the most serious microvascular complications of diabetes and a major cause of end stage renal disease, diabetic nephropathy (DN) is calling for effective treatment strategies. Here, we provide evidence that hyperglycemia can induce proliferation and decreasing apoptosis of mesangial cells (MCs) and subsequent renal dysfunction by up-regulating cellular FLICE-inhibitory protein (cFLIP). Treatment with emodin significantly turns down the accelerated cell cycle and proliferation of MCs… CONTINUE READING
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